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Mediator is known as a transcriptional regulator/initiator complex 50,51
In summary, we conclude that the glutathione system is the dominant mediator of antioxidative electron flux under pronounced pro-oxidative conditions across different eukaryotic kingdoms
Nanoparticles have also been developed to improve wound healing, mainly via ROS scavenging, anti-inflammatory and antibacterial effects, and applied to several in vitro and in vivo models 180,181,182,183,184 , as well as other molecules 185,186,187,188
These cytokines also downregulate GPX4, further sensitizing chondrocytes to ferroptosis
