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Research has shown that in HGSOC with a deficiency of tumor-infiltrating lymphocytes, EZH2 expression in cisplatin-resistant tumors is nearly twice that of normal tumors ( The high intratumoral heterogeneity (ITH) in HGSOC results in diverse molecular characteristics at different stages, consequently affecting its sensitivity and resistance to chemotherapy ( The composition and structure of the tumor microenvironment directly influence drug delivery efficiency

NAC provides cysteine (the bottleneck amino acid for glutathione synthesis) in a form that survives digestion and enters cells efficiently

An increased serum ratio of Cu/Zn is positively associated with lung cancer [95], aging [96], pneumonia [97], and ischemic heart disease [98]