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Common signs include: Burning or shooting nerve pain in your feet Tingling sensations that may worsen at night Numbness that typically starts in the toes and spreads upward Increased sensitivity to touch or temperature Muscle weakness affecting balance and coordination Loss of reflexes in the feet and ankles Difficulty sensing foot position, increasing fall risk Symptoms often manifest gradually and may be mild at first

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The activation of polyamine flux in adipocytes facilitated the polyamine acetylation reaction by using acetyl-CoA, ultimately leading to the loss of fat [44]