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We next evaluated the possible crosstalk between JNK and ERK in HCH plus BSO-mediated apoptosis of K562 cells, keeping in mind that JNK negatively regulates ERK activity [35], [36], [37]

In stark contrast to other prevalent cancers, such as breast, lung, and prostate, which are experiencing declining mortality rates, HCC-related mortality continues to climb at a rate of 23% annually [2]

Overall, we most commonly predicted CATs sequences that localise to the cytoplasm (24 sequences), but also the mitochondria (2 sequences), nucleus, cell membrane and extracellular space (Fig