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This peripheral inflammation is a known driver of neuroinflammation, which is implicated in mood disorders, cognitive decline, and neurodegenerative diseases

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[16] [121] Upon leaving the stomach the hydrochloric acid of the chyme is neutralized in the duodenum by bicarbonate, [122] and pancreatic proteases release the vitamin from HC, making it available to be bound by IF, which is a protein secreted by gastric parietal cells in response to the presence of food in the stomach