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A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*28 allele However, the precise dose reduction in this patient population is not known Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Other polymorphisms of UGT due to random genetic differences have been reported, but only a few have suggested to influence drug metabolism in the clinic

In the context of critical limb ischemia (CLI) in murine models, TB-500 appears to have pro-angiogenic potential, as suggested by researchers