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[53] evaluated the therapeutic efficacy of APTATstat3-9R, a high-affinity peptide conjugate that inhibits signal transducer and activator of transcription 3 (STAT3) phosphorylation via cell-penetrating 9-arginine motif modifications, a STAT3 phosphorylated cell-permeable peptide inhibitor, for the indication of improving PF

However, these treatments often rely on enema or oral administration, which generally suffers from limited rectal retention time, insufficient local drug exposure, or low systemic bioavailability, thus limiting efficacy stability and patient compliance [7, 9]

L-octanoylcarnitine oxidation exerts a profound regulatory effect on the outer mitochondrial membrane's permeability to ADP, a critical factor in cardiac bioenergetics