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These pathological changes have been associated with progressive reductions in gray and white matter volumes in critical brain regions responsible for cognitive functions 13,25

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Nelson S.K., Bose S.K., Grunwald G.K., Myhill P., McCord J.M

Previous studies have shown that patients with liver cirrhosis or HCC had decreased plasma GSH concentration [911] and GSH-dependent antioxidant enzyme activities [2,5,12]

After overeating, Wnt/-catenin signal transduction in adipose tissue is inhibited, manifesting as increased expression of inhibitors of the canonical Wnt signalling pathway, such as SFRP2, FRZB/SFRP3, and DKK3, and increased phosphorylation and total GSK-3 levels