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Description
What makes NNMT a significant metabolic target
NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1
Furthermore, there was no accumulation in any of the organs tested
This therapy has big benefits
