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Description
Characterized by a bluish to purplish pigmentation, vascular dark circles are the result of a slowed blood microcirculation

TPMT genetic polymorphism represents a striking example of the clinical importance of pharmacogenetics

It is an enzyme that plays a key role in the modulation of catecholdependent functions such as cognition, cardiovascular function, and pain processing

doi: 10.1196/annals.1413.020