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However, alternatively activated, hemoglobin-scavenging CD163 + macrophages are present within atherosclerotic lesions and were also proposed to promote angiogenesis, vessel permeability, and leucocyte infiltration, via the CD163/HIF1/VEGF-A pathway, thereby exacerbating plaque progression (155)

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It can involve all parts of the scalp but nape of the neck is often affected