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Description
PLoS One 14:e214250
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By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance ( IDO1 plays a key role in immune escape in AML, but targeted therapy is still in the early stage of exploration
In a standard Gaussian distribution, this central interval captures approximately 68% of the total population
