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Remarkably, the submicromolar doses of trigonelline efficiently suppressed NRF2 nuclear accumulation and proteasome activity, abolishing their protective effects in vitro and in vivo.69 Brusatol: Brusatol, a quassinoid plant extract from Bruceajavanica, traditionally used in Chinese medicine for treating various diseases, including cancer amoebic dysentery, and malaria.7072 Ren et al

Astrocytes can also regulate neuronal activity by releasing gliotransmitters such as glutamate, ATP, D-serine, or GABA, also known as gliotransmission

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In agreement with the proteome data, transcriptome results point to an up-regulation of Cys biosynthesis and down-regulation of GSH biosynthesis under infection-like conditions