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As discussed above, numerous studies have reported efficacy of both agonists and PAMs of mGlu 2 to decrease taking and seeking of various drugs of abuse, lending support to the idea that despite adaptations in mGlu 2 function caused by chronic drug exposure, pharmacological interventions remain a viable strategy for correcting drug-related behaviors

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Results showed a 22% increase in measured skin firmness and a 16% reduction in fine lines as assessed by optical profilometry

You can make this point to your physician if you think doing so might minimize the ruffling of feathers