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Description
The approval was backed by the Phase II open-label AGAVE-201 trial, where treatment with a 0.3-mg/kg dose of Niktimvo elicited an overall response rate of 75%, with a median time to response of 1.5 months
Meanwhile, the omega-3 PUFAs and their eicosanoid derivatives 17,18-EEQ (Epoxyeicosatetraenoic acid) activate the TRPV4 function in endothelial cells by increasing the intracellular Ca 2+ to modulate vascular reactivity [12,36]
DOI: 10.46497/ArchRheumatol.2022.9109
Date of Mfg ( Scrub)
