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In these studies, patients experienced elevated rates of adverse reactions, including weight loss, decreased BMI, decreased appetite, insomnia, infections (upper respiratory and nasopharyngitis), irritability, and affect lability
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Although humans contain a gene (ACADL) that encodes a long-chain acyl-CoA dehydrogenase (LCAD) enzyme, expression of this gene in humans is poor and the encoded enzyme does not contribute to mitochondrial long-chain fatty acid -oxidation
doi: 10.1136/bmj.327.7414.557
