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It is twice as common in women than in men, hence, it was relabeled early on as stiff-person syndrome instead of the original stiff-man syndrome. Patients typically present with muscle spasms and stiffness, concurrently in the thoracolumbar paraspinal and abdominal muscles, resulting in difficulties turning and bending (28

This varies, but most protocols recommend a minimum of 8 to 12 weekly sessions as an initial course, followed by monthly maintenance

We previously showed that IGF-1Rs are overexpressed in primary prostate cancer (PCa) and are further upregulated on progression to androgen-independent metastatic disease 2,3

Padilla F, Brenner J, Prada F, Klibanov AL