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Moreover, proinflammatory and lipotoxic sphingolipid metabolites implicated in MASLD/MASH, including sphingomyelins, ceramides and hexosylceramides 3,43,44 , were significantly decreased in livers from mice overexpressing AGXT (Fig

3.4 Risk of inducing stable resistance An additional critical concern when therapeutically exploiting DTP reversibility is the risk of unintentionally facilitating the transition of persister cells into genetically stable, irreversibly resistant populations (Mieras et al., 2016

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