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The role of genetic defects in carnitine-associated hepatic encephalopathy: a review of literature

Acylcarnitines produced as products of incomplete mitochondrial fatty acid oxidation have been detected in obesity, type 2 diabetes, cardiovascular disease, encephalopathy, and diseases of the eye, while patients with peroxisomal biogenesis disorders, such as Zellweger syndrome or X-linked adrenoleukodystrophy, or with acidemias have abnormal profiles of circulating acylcarnitines
We then obtained basic demographic information, medical and psychiatric history, the Structured Clinical Interview for DSM-IV (SCID) to establish the diagnosis of bipolar depression and any other comorbid Axis I disorders, physical examination, vital signs, electrocardiogram, and laboratory tests