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MTX-induced increase in intestinal permeability is mediated by the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-B) pathways
V.Hensley-SimonM.Tahsili-FahadanP.LaLumiereR

This has led to hypotheses about indirect roles via sleep regulation and immune activity, though the research is still at an exploratory stage
