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Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimers disease: A 6-month, randomized, placebo-controlled, multicenter trial

however, this traditional notion is challenged by recent studies showing that the gutliver axis rather liver alone plays an important role in systemic acetaldehyde clearance

Studies lasting up to five years show no adverse effects on kidney or liver function when used at recommended doses
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