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Description
S-adenosylmethionine synthetase (SAM, encoded by the metK gene) is a methyl donor that provides a methyl group to several reactions necessary for primary and secondary metabolism
Staff writers Carl Steward and Diamond Leung contributed to this notebook
H-bond donation to the reacting oxygen has an accelerating effect via increasing its electrophilicity, and H-bond donation to the leaving oxygen stabilizes the transition state (as well as the leaving group) and decreases the activation energy
Once administered, d-glutathione circulates through the bloodstream and supports detoxification pathways in the liver
