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Description
The following populations have no published exposure data and would generally be excluded from research-context use: - People who are pregnant, trying to become pregnant, or breastfeeding

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Whether they reflect dose-related issues, sourcing variability, or true pharmacological effects is unknown, precisely because the human data does not exist to answer that question
In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression