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These results collectively indicate that Sirt1 is indispensable for NNMT-mediated regulation of glucose metabolism, and both NNMT and MNAM have the ability to upregulate Sirt1 expression

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Babault N, Allali-hassani A, Li F, Fan J, Yue A, Ju K, Liu F, VedadI M, Liu J, Jin J (2018) Discovery of bisubstrate inhibitors of nicotinamide N -methyltransferase (NNMT)

What the evidence really shows This is the key part: when AOD-9604 was tested in human weight-loss trials, the results largely did NOT show a strong effect