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Antibiotics severely decreased the number of tumors in the distal colon of Apc +/Min /Stard7 IEC mice, thus demonstrating that tumor development in these mice is partially microbiota-dependent (Fig

Nevertheless, longer-term exposures are frequently studied, often in combination with multiple time points, to examine the time-course variation of the metabolome, to understand the sequence of molecular initiating events leading to an adverse outcome pathway, and chronic toxicity upon repeated exposure to a given compound (Silva et al., 2013

doi: 10.1523/JNEUROSCI.2893-16.2017 33 FiliceFJanickovaLHenziTBilellaASchwallerB