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While several botanical drugs have been used clinically to alleviate alcohol-induced liver damage and prevent its progression to cirrhosis or liver cancer, the exact mechanisms by which they regulate hepatocyte function remain poorly understood, raising concerns about potential side effects (Barnes et al., 2010)

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Lactate shuttling links histone Kla, particularly H4K12la, to neural stem cells (NSCs) proliferation through murine double minute 2 (MDM2)-p53 signaling pathway and eventually regulates cell cycle and endows NSCs neurogenic potential in the adult hippocampus

Nevertheless, therapeutic hypothermia is only partially effective (5760), and many infants with HIE remain at substantial risk of death or severe long-term neurodevelopmental impairments (55)