chronic fatigue and b12 injections not working Are Vitamin B12 Shots Right for You? Pernicious Anemia: Definition, Symptoms, Causes

Last updated on Mar 30, 2026

In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

Deficiency causes multiple problems, but adequate or excess B12 provides nothing but benefits to your energy, strength, and mental sharpness

This compound is commonly studied in connection with the enzyme nicotinamide N-methyltransferase (NNMT)