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And among the proteins that make up the thickened cell envelope, small proline rich proteins, also known as stress-inducible proteins, are expressed that protect keratinocytes from ROS ( Superoxide Dismutase SOD is a highly conserved enzyme, that is abundantly expressed in the cytoplasm of aerobic organisms and plays a fundamental role in protecting cells from oxidative stress

10.3390/nu11081822

Goyal MS, Hawrylycz M, Miller JA, Snyder AZ, Raichle ME

The Stanford PNAS study noted striking sex-specific differences in this regard, finding that male ME/CFS and Long COVID patients exhibited pronounced mitochondrial lipid oxidative damage mediated by a failure in Glutathione Peroxidase 4 pathways