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In addition to 2D cell culture, 3D organoid systems or co-culture systems with stromal fibroblasts, immune cells or endothelial cells have increased translational relevance by modelling the tumour microenvironment, heterotypic signalling and drug penetration kinetics (219, 220)

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PMID: 41454998 Cells A Comprehensive Adenoid Cystic Carcinoma-Derived Organoid Platform for Disease Modeling and Drug Screening Captures Interpatient Heterogeneity