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Tryptophan catabolism can also be initiated within non-hepatic tissues by the enzyme indoleamine 2,3-dioxygenase 1 encoded by the IDO1 gene

For mortality from influenza and pneumonia, the main effect of testosterone was not statistically significant (HR = 0.94 [0.77, 1.15]), but there were significant interactions between testosterone and the final two age splines (spline-2: HR = 1.62 [1.18, 2.24]