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In the nervous system, inhibition of mTOR pathway, including its downstream effectors p70S6K and 4E-BP1, usually promotes neuronal apoptosis 11

Whether the epigenetic mechanisms affect multiple ferroptosis genes and how these different epigenetic mechanisms corporate with diverse signaling pathways to determine the responsiveness of cells to ferroptosis stimuli remain unknown

FIGURE 3 7.1 Flavonoids: multitarget antioxidants and metabolic regulators Flavonoids exert hepatoprotective effects through synergistic mechanisms that include direct ROS scavenging, activation of antioxidant pathways, and metabolic regulation

The 5mg dose is usually the second step in the standard tirzepatide escalation schedule