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10.1167/iovs.10-5289 Invest

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These novel strategies break through the limitations of traditional symptomatic treatment and focus on targeting the core pathogenic mechanism of immune-inflammatory dysregulation, holding great translational potential for improving the clinical outcomes of varicocele patients

Increasing NAD + levels by supplementing NR in mouse tissues and mammalian cells activates SIRT1 and SIRT3, which ultimately leads to increased oxidative metabolism and prevents metabolic abnormalities induced by HFD