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Recall that because of its highly polar structure, liquid water can act as either an acid (by donating a proton to a base) or a base (by using a lone pair of electrons to accept a proton)

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Common Examples Non-selective NSAIDs (COX-1 & COX-2 inhibitors) Ibuprofen Diclofenac Naproxen Indomethacin Ketoprofen Aspirin COX-2 selective inhibitors Celecoxib Etoricoxib Meloxicam (preferential) 4