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Most organic radiosensitizers are type-1, which enhance radiotherapy by modulating cell responses, such as reducing the radioresistance of tumor cells, preventing the formation of blood vessels (or disrupting the existing vessels, anti-angiogenic), inducing apoptosis and suppressing mitosis 3,6,8

Notably, a study in A plaque-bearing Tg2576 mice, initiated at 14 months of age, showed no significant impact on relieving oxidative damage, even with elevated plasma melatonin levels [165]

SOD converts O 2 to the more stable hydrogen peroxide (H 2 O 2 ) (McCord and Fridovich, 1969)