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After the folate cycle, through the interconnection with the methionine cycle involving the entry of cobalamin (vitamin B12), folic acid is again synthesised

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As a result, molecules including GPx1, NQO-1, HO-1, and -GCS are excessively produced, and they control the production of GSH (97, 99)

Several factors including obesity and excessive consumption of calorific foods, beverages high in sugar content, trans-unsaturated and saturated fatty acids, and red or processed meats are known to increase the risk of developing various tumors, whereas diets high in whole foods such as grains, vegetables, and fruits are thought to reduce this risk