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A change occurred when a new pain model was created involving surgical injury to peripheral nerves, which generated symptoms similar to peripheral NP conditions [273]

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In the systemic circulation, metal-based NPs could absorb a variety of proteins like albumin, immunoglobin, and other functional biomolecules to the surface of metal-based NPs to form a protein corona, which has been reported to alter the surface properties of metal-based NPs (Duran et al., 2015

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