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Proof-of-concept therapeutic treatments, which overcome the impaired R152H GPX4 activity, including selenium supplementation, selective antioxidants and a deuterated polyunsaturated fatty acid were identified

Taken together, these findings indicated that P-Mn/TI@mHSA effectively mitigated progression of atherosclerosis through a combination of a multi-stage delivery strategy, reduction of oxidative stress, and TRAF6 inhibition-mediated suppression of inflammation

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