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Combination therapy with pegylated liposomal doxorubicin and carboplatin in gynecologic malignancies: a prospective phase II study of the Arbeitsgemeinschaft Gynekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and Kommission Uterus (AGO-K-Ut)

After reaching the tumor site, the acidic microenvironment and endogenous GSH can rupture the nanoparticles to release the drug, in which Cu 2+ reacts with endogenous GSH and H 2 O 2 to generate ROS, and HND not only exerts the effect of chemotherapy, but also amplifies the endogenous H 2 O 2 through intracellular oxidoreductase to amplify the oxidative stress in a cascade on-demand together with Cu 2+ (Fig

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Key Project of the Science and Technology Commission of Shanghai Municipality (23J21901500)