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, compromised blood brain barrier resulting in increased permeability, increased activation of microglia and astrocytes producing pro-inflammatory cytokines, and damaged myelin/white matter tracks [9], [24][36])

A single acute high-intensity interval exercise increases AMPK, Acetyl CoA carboxylase (ACC), Ulk1 protein expression, and Drp1 phosphorylation, promotes mitochondrial fission and mitophagy, and improves the anti-fatigue ability of skeletal muscle of mdx52 mice ( 5.1.3 Resistance exercise intervention Resistance training positively modulates mitophagy

15 They explain that vitamin C is a cofactor for the enzyme peptidylglycine -amidating monooxygenase (PAM), 137 the only known enzyme in humans capable of making essential modifications to peptide hormone precursors

The pro-inflammatory milieu intensifies neuronal damage, compromises bloodbrain barrier integrity, and exacerbates reperfusion-induced damage