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Among all tested strains, the highest MLM content of approximately 6.7 mol% was observed in recombinants ACSM4 gat2 and ACSM4 lro1 , which increased by 60.4% compared to the control (Fig

Therefore, this paper proposes the Common Messengers, Dual-Axis Convergence model to systematically elucidate how the gut microbiota, through a shared set of messenger molecules, simultaneously and independently drives lipid and glucose metabolic dysregulation via the gutadipose and gutpancreatic axes, ultimately leading to the comorbidity of MAFLD and T2DM

In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression
