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One possible cause is the insufficient drug levels in the brain

J., 29: 13-20, 2000
[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Lucena M.I., Andrade R.J., de la Cruz J.P., Rodriguez-Mendizabal M., Blanco E., Snchez de la Cuesta F
Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines
