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Four molecule families have peer-reviewed clinical evidence supporting their use in microinfusion-style delivery: copper tripeptide GHK-Cu (collagen synthesis, gene-expression modulation), recombinant epidermal growth factor or sh-Oligopeptide-1 (keratinocyte proliferation, dermal restructuring), polydeoxyribonucleotide PDRN (adenosine A2A receptor activation, fibroblast stimulation, anti-melanogenesis), and a multi-molecular-weight hyaluronic acid system (50 kDa to 2000 kDa fractions, each with different penetration depth and biological role)

Studies have shown that CAFs upregulate levels of C-C motif chemokine ligands such as CCL2, CCL5, and CCL20 to coordinate activation of HCC cell ERK/PKM2 and TGF- pathways to enhance tumor metastasis phenotype and regulate tumor metabolism (135, 136)

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H.HeadE.et al (2012)