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It also directly neutralizes hydrogen peroxide and lipid peroxides via glutathione peroxidase, and is required by glutathione S-transferases for detoxification of xenobiotics and reactive metabolites

For example, GPx1 has been reported to prevent oxidative DNA mutations, which in turn may prevent the development of tumors [42], and research shows that overexpression of GPx1 can reduce tumor growth, indicating its inhibitory effect in tumorigenesis [43]

2003;285:H2309H2315

There have been isolated reports of reversible hepatic injury following intravenous glutathione administration, emphasizing the need for careful monitoring, especially with repeated or high-dose therapy