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This highlights the potential to exploit HO-1 as a valuable target for therapeutic intervention in DFU cases (Fig

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not intended as therapeutic claims.) NAD+ is frequently utilized in studies exploring: Mitochondrial energy production and oxidative metabolism Redox balance and cellular respiration mechanisms Sirtuin pathway activation in biochemical assay models DNA repair and genomic stability pathways (PARP-related studies) Metabolic function, insulin-signaling pathway mechanics, and ATP production assays Cellular stress response and oxidative-damage models Neurobiological metabolism and biochemical signaling investigations Its central role in NAD+/NADH cycling makes it a critical molecule for metabolic and biochemical research.

Several research studies have found it improves microcirculation and aids in healing
