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This association with increased risk of CVD with higher TMAO levels was reduced but not eliminated when the authors adjusted their data for other known CVD risk factors, thus establishing higher TMAO levels as an independent risk factor for heart attacks and strokes (1)
Although various attempts have been made to discover metabolite biomarkers for the diagnosis and treatment response of MDD, problems with sample size and consistency of results have limited clinical application
Microb Cell Fact 6 , 31 (2007)
[DOI] [PubMed] [Google Scholar] 103.Clarke BE, Brown DJ, Xipell JM
