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GHR is a 638 amino acid long homodimeric receptor with one cytokine receptor homology domain (CRH), a single-pass transmembrane domain, and cytoplasmic intracellular domain (ICD) (Figure 1)

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Thus, CAT protein may be S -nitrosylated under GSNO and this modification may increase CAT activity because of S-nitrosylation caused by GSNO