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Female APOE4 mice showed an upregulation in the mitochondrial dysfunction pathway but a down regulation in mitochondrial protein import, complex III assembly, TCA cycle, and glyoxylate metabolism and glycine degradation pathways ( Figure 2C )

Animal models could be of help in better understanding the molecular basis of MVP, possibly providing sufficient information to tackle specific mechanisms aimed at slowing down MVP progression, therefore developing non-surgical therapies impacting on the natural history of this condition

[DOI] [PubMed] [Google Scholar] 225.Giacco, F