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Initially, we found that genes whose expression is upregulated in FH-deficient cells 8 are significantly enriched with oxidative stress genes (hypergeometric P value of 5.505e04, see Methods)

doi: 10.1073/pnas.96.12.7088 5 AllardJBDuanC

doi: 10.1016/j.phytochem.2011.02.012 230

This detoxification reaction is carried out by the glyoxalase system
