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Above all, there were substantial heterogeneities among the included studies, indicating the differences in terms of participant baselines, study designs, and statistical methods, and thus, the conclusion drawn may to some extent not be convincing

(TIF) Abbreviations anti-PD-1: anti-programmed death-1 anti-PD-L1: anti-programmed death ligand-1 AIH: autoimmune hepatitis ALP: alkaline phosphatase ALT: alanine transaminase CYP: cytochrome P450 DI-AIH: drug-induced autoimmune hepatitis DILI: drug-induced liver injury ICI: immune checkpoint inhibitors INR: international normalized ratio irAE: immune-related adverse event NAPQI: N-acetyl-p-benzoquinone imine RCT: randomized clinical trials RUCAM: Roussel Uclaf causality assessment method Declarations Acknowledgement We would like to sincerely thank Kyoko Yoneda (Yokohama City University) for her assistance in preparing the figure

Healthy RBCs promptly convert metHb back into Hb with the help of NADH-cytochrome b5 reductase, supported by reductants like NADPH, glutathione, and ascorbic acid to prevent adverse reactions [8,20]

This review describes the history of mc 2 155, its use in developing genetic tools for pathogenic mycobacteria, and its application to characterizing biological mechanisms and targets of TB drugs (Fig
