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For patients with more severe or refractory pain, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen reduce prostaglandin-mediated inflammation by inhibiting cyclooxygenase-1 and cyclooxygenase-2, key enzymes in producing PGE2 (Banaszewska et al., 2022)

Carneiro SB, Costa Duarte FI, Heimfarth L, Siqueira Quintans JDS, Quintans-Jnior LJ, Veiga Jnior VFD, Neves de Lima AA (2019) Cyclodextrindrug inclusion complexes: in vivo and in vitro approaches

militaris exhibit mitogenic effects in mouse splenocytes and can promote differentiation of murine T-, B-lymphocytes, and neutrophiles
